The Department of Chemistry will host Mark Levin, an associate professor at the University of Chicago, for a Chemistry Colloquium titled “Single Atom Logic for Skeletal Editing” on Tuesday, November 15 from 3:15–4:30 p.m. in Room 111 of the Robert A. Pritzker Science Center.
Mark Levin – Department of Chemistry – University of Chicago
Reactions that can manipulate the connectivity of the molecular skeleton are under-explored as tools for late-stage functionalization, in part because their implementation has been hindered by their often nonintuitive retrosynthetic logic. This presentation will cover transformations discovered in our laboratory which address this challenge by enabling single-atom changes to aliphatic and aromatic systems through the insertion and deletion of single heavy atoms (C,N,O, etc.), as well as more complex manipulations leveraging combinations of these elementary transformations. Our approach to this problem is modality-agnostic, drawing from a wide range of reactive species and synthetic disciplines (organometallic chemistry, reagent design, photochemistry). Applications to late-stage functionalization and diversification of complex pharmaceutically relevant compounds as well as unique opportunities for synthesis will be presented alongside mechanistic findings.